Sunday

Yes, racism is still very much alive and will always be here.....

CC™ Editor's VideoSpective


This ABC experiment on racial prejudice is quite revealing and speaks not only to the prejudices carried by the "majority", but those unfortunately imbibed by the recipients, as a result of centuries of a sense of diminished self-worth, resulting from institutional and related racial prejudice.

Watch and learn.....


Thursday

Wednesday

Ten things we've learnt about identity politics in the United States

CC™ Editor-in-Chief
--- Boyejo A. Coker

a) Racism is an institution not an event, statement or action, as evident by the silence and acquiescence of the Republican members of Congress to the dangerous and highly-charged statements, and actions of former President Donald Trump for 4 years, that ultimately culminated in the violent insurrection by White Supremacist supporters of his, against the Congress of the United States on January 6th, 2021. His rhetoric hasn’t changed since he left office, as despite being convicted by a U.S. Court on 34 counts among other legal hurdles he faces, he remains in pole position to regain office as the 47th President of the United States.

b) Former House Speaker Nancy Pelosi actually instigated the singling out (in 2019) of the women of color in the U.S. House by referring to them as "just four people with no following". That was all Donald Trump needed to strike at the time, against those women. 

c) Donald Trump "is not a racist". The power structure that enabled him become the POTUS (still incredibly threatens to bring him back in 2024), and continues to facilitate his trampling upon the Constitution with impunity, is racist, and was set up to be that way by the founding fathers, who enslaved the Africans that were brought to America and saw them as less than human.

d) President Barack Obama would not have been elected to office if he had bragged about sexually assaulting women, and he would definitely have been impeached, and removed from office, if he had conducted himself in office as Trump did.

e) Imagine what would have happened if Barack Obama had asked those that criticized his administration to leave the country, if they did not like the way things were being done. Or worse still, if he (Obama) had threatened to unleash the U.S. military on American citizens, protesting in the streets. Lastly, I am confident Barack Obama would have been impeached and convicted within a week (at most) if he had instigated an insurrection against a co-equal branch of government. White privilege, an indulgent by-product of White Supremacy is responsible for Donald Trump’s ability to remain relevant in the American political landscape. 

f) Gratitude is not a requirement of citizenship. Furthermore, all U.S. citizens (naturalized or natural born) have equal rights, or do they.......?

g) The old order of the Democratic party is completely out of touch and the treatment of the four women Representatives of color by former Speaker Pelosi four years ago, serves to buttress that point.

h) The Republican party has always had a playbook steeped in identity politics. Anyone remember the Willie Horton ads? Trump and his Harvard educated running mate are not doing anything new, with regard to the demonization of Haitian immigrants in Springfield, Ohio, they simply took a time-tested and proven page out of the Republican playbook of identity politics. 

i) The palpable silence of the so-called religious leaders (especially the white religious leaders) in the United States tells you all you need to know about them.

j) The silence of most top American CEOs and business leaders (until recently) also tells you all you need to know about them and their organizations. The ones that have 'spoken out' are not only late to the game (they are still Trump’s biggest donors and supporters by the way), but are speaking out merely to 'sanitize' their brand, as well as clear whatever is left of their conscience (assuming most of them actually have one).

Monday

Band of thieves and purveyors of ineptitude.....

"BARBARIANS AT THE GATE"
CC™ Viewpoint 
By Boyejo A. Coker - Editor-in-Chief

It actually does not matter what aisle of the 'political' spectrum you belong to, this rudderless leadership has failed Nigerians, more-so even worse, since the inception of the 4th Republic in May, 1999.

The Peoples Democratic Party (PDP) held sway for fifteen mostly inglorious years (1999-2015) under the stewardship of the following:

a) Rtd. General Olusegun Obasanjo (1999-2007)

b) The late Umaru Musa Yar'Adua (2007-2010)

c) Goodluck Ebele Jonathan (2010-2015).

For at least 12 of those first 15 years of the 4th Republic, corruption, by and large, became the norm while the climate created by avaricious greed, further engendered a general state of lawlessness.

Kidnappings and killing orgies became commonplace and have continued unabated, till today.

While some may say that there was a certain degree of accountability, with the accompanying restoration of some semblance of sanity during Yar'Adua's brief reign, the truth remains that his vision of a better Nigeria was never going to see the light of day, given the scavengers and marauders he was surrounded by.

For this piece, we will absolve Umaru Yar'Adua of some of the PDP misrule when one considers that he was never in charge, as the cabal (whose stranglehold on the proverbial throat of Nigeria has never been in doubt) led by the one Olusegun Aremu Obasanjo et al essentially pulled his strings. When he (Yar'Adua) then dared to think for himself, he was murdered by the demonic powers behind the Nigerian throne of oppression.

Then came Olusegun Aremu Obasanjo again, as in his quest to maintain his inordinate hold and that of his fellow 'barbarians at the gate' on the destiny of Nigeria, he ensured that the next Nigerian leader would come from his "political family tree' (unfortunately, nothing good has ever come from any Obasanjo tree including his biological family tree). Thus, the dysfunctional reign of Goodluck Ebele Jonathan, an absolute and utter misfit for any public office, was visited upon Nigerians.

It remains telling that only Goodluck Ebele Jonathan could have made an ethnic and religious bigot attractive to the same Nigerians that had rejected him (Muhammadu Buhari) a resounding three times (2003, 2007 and 2011) prior to his resounding victory in the 2015 general elections.

In case some have forgotten how we got here, this was the "scorecard" of the PDP misrule, particularly under Jonathan:

a) Coffers-to-personal account accountability (or lack-there-of) where public funds were used for personal gain including the extravagant wedding of GEJ's daughter http://www.myjoyonline.com/…/goodluck-jonathans-daughter-re….

b) An aviation industry (once led by Femi Fani-Kayode and then later by the certificate forging Stella Oduah) that was nothing short of a death trap. I should know as I lost a close relative, Deji Falae (Ondo State Commisioner for Culture and Tourism at the time) to one of those unfortunate but far-too-common air crashes under the PDP misrule.

c) Fabricated economic numbers embellished masterfully by sycophants in the Finance and Economic Ministries to obfuscate the fact that the average Nigerian could not afford the most basic amenities under the Jonathan misrule.

d) Religious over-reach where Jonathan consistently employed openly the advise and services of so-called Christian Pastors and even embarrassed the country by taking his whole cabinet to Israel to "pray". Can you imagine the outcry from the same hypocritical CAN (Christian Association of Nigeria) and their egunje leadership if PMB had gone to Saudi Arabia with his whole cabinet to pray?

e) Under Jonathan, the bigotry and balkanization of Nigeria was effectively set in motion as Jonathan was essentially committed to the disintegration of Nigeria; and this was made even more apparent with the systematic decimation of the Nigerian Armed Forces. Jonathan, in an act of subterfuge against the Nigerian state, then employed foreign mercenaries (former South African soldiers under the apartheid racist regime) to fight Boko Haram at the end of his unfortunate misrule. 

f) Do Nigerians also forget that Jonathan attempted to scuttle the democratic process during this period of shame and disgrace to the Nigerian nation by postponing the elections?

g) The use of the DSS to terrorize, intimidate and kill (thousands of people disappeared without trace) Nigerians in the North, the SE and the SW (in particular) with Femi Fani-Kayode, Ayo Fayose and Musiliu Obanikoro leading the assault on political opponents in the SW with the firm support of the DSS, much like the days of Nazi Germany. Unfortunately, that weaponization of a State Security apparatus against the citizenry has continued under the autocratic administration of Muhammadu Buhari.

h) Nigeria became a pariah state under Jonathan and effectively lost its voice both on the African continent and globally. Anyone who underestimates the forces that are against this current administration with its stated desire to sanitize the nation must be truly misinformed. The forces are both spiritual and physical and I will caution Nigerians that those who forget the past are condemned to repeat it.  

And the circus has continued under the rudderless and despotic rulership (note I didn’t use the term leadership) of Muhammadu Buhari, who has proven himself to be just as incompetent a leader as he was as a soldier. Sadly, the teeming masses of hardworking and highly industrious Nigerians remain saddled with an unbecoming band of brigands and marauders as so-called leaders.

Nigerians need to realize that they are merely pawns in the game of high stakes chess being played by a corrupt and morally bankrupt political class. The truth is they (the political class) even intermarry and are not bothered by ethnic or religious so-called differences, while at the same time fanning the embers of ethnic and religious warfare among the desperately poor who just would like to have a fair shake in life, for once. 

As the late Sunny Okosun said in his famous song from almost three decades ago, "Which way Nigeria. Which way to go?" The answer lies squarely in the hands of the Nigerian people and the sooner they realize how much power they have to make a change, the sooner that change will come.  

Heaven, as they say, helps those who help themselves. 

Great African Civilizations Through History

CC™ VideoSpective

Tuesday

Flashback: The GOP and the dearth of true conservatives

Reagan takes oath of office
Editor-in-Chief 
--- Boyejo A. Coker

This piece was written (ahead of the 2012 U.S. general elections) as a sequel to a preceding piece titled "Whither the GOP and true conservatism." Both pieces served to profess a prelude to the emergence of both Barack Obama and Donald Trump on opposite sides of the political spectrum. The article continues below.....

In an article I wrote a few years ago, I touched on the debilitating frailties of the GOP as presently constituted and how they may have led to the election of Barack Obama as the 44th President of the United States.

As we get into the decisive months of presidential politics in the U.S. general elections, one sees the same pattern beginning to unfold once again, as the GOP-led Congress (at least on the House side) would much rather play side-bar politics, that could ultimately re-energize the left to turn out in solidarity of what most observers perceive to be an under-performing president.

There is no question that the president is vulnerable and worse-still is the fact that he seems unsure of what he needs to do, in order to get the economy moving again.

For independent voters (they hold the "swing votes" in key elections), the two choices for the White House would seem to be a replay of 2008 all over again.

Then, most independents seemed to initially lean towards John McCain, as they respected his service to country as well as his penchant for reaching across the aisle, to get the business of the nation done, when it was absolutely necessary.

The fringe right of the GOP was however cool to the McCain candidacy and they eventually forced his hand into choosing someone that many felt became a liability to both his candidacy as well as the poignant message true conservatives were trying to send to the American people.

Key political watchers would argue that true conservatives never warmed up to Sarah Palin the minute they realized there was nothing behind the looks or between the ears.

For all the so-called Tea Party would like most Americans to believe, conservatism is not defined by a resentment for a sterling educational pedigree or impeccable intellectual acumen. Rather than see those with the preceding qualities as snubs, a true conservative views the composite as an invaluable asset; one that typifies a sense of ambition, responsibility and ultimately speaks to the crux of the conservative message of a commitment to excellence.

The reality is that this president is way in over his head, but the GOP leadership in the House of Representatives has consistently giving him a way out by stalling and styming his feckless efforts aimed at "reviving" the American economy.

And when they are not styming the president's "well intended efforts" they are busy issuing subpoenas to the Attorney General of the United States for a program that was actually started under a Republican president; it was then called Operation Wide Receiver and it was the first known ATF "gunwalking" operation to the Mexican drug cartels, beginning in early 2006 (under the Bush White House) and ran till late 2007.

Not to digress onto this matter, but what makes the Darrell Issa-led over-reach even more laughable and at best mis-directed, is the fact that under the Bush administration, there were no known reviews by either the DOJ or the Congress at the time. In fact, it was not until Barack Obama took office in 2009, that the Eric Holder-led DOJ started an intensive review into Operation Wide Receiver, with arrests and indictments subsequently made, as a result of the investigations.

Rather than focus on the key issues that continue to affect the generality of the American people, the ECONOMY, ECONOMY and the ECONOMY, key GOP leadership and their surrogates, would much rather play divisive politics and once again, give a much needed opening and life-line to a struggling presidency.

True conservatives are not blinded by their parochial and ideological idiosyncrasies, but are instead committed to espousing the true values and ideals of transparency, accountability and responsible governance; doing so with dignity and firmness, as well as a sense of cordiality that belies their resolve and determination.

The message of individual responsibility, self-determination, personal discipline and accountability must not be lost in the abyss of incendiary vituperations laced with jingoistic redundancies.

The American people deserve much better this time around, than a default presidency as that may ultimately lead to a couple of plausible scenarios that could eventually obtain here. The first is that Barack Obama's "third term" is ensured (4 years from now) by the lack of purpose and direction currently being exhibited by the core GOP establishment. The other scenario is that an anti-establishment candidate may arise out of the ashes of the impending GOP establishment's implosion. That person would then become an unlikely but much welcome voice (to the far right) of parochial irredentism that may change the political landscape of the United States forever.

Chief Editor's commentary: The 'anti-establishment candidate' I predicted almost a decade ago, in this piece, turned out to be Donald J. Trump. Four years of his chaotic presidency has turned American democracy on its head and January 6, 2021 was indeed a defining day in the history of the United States of America. Let no one be fooled here either by the incendiary posturing of some GOP fringe stalwarts of the disgraced former president, as it relates to Putin’s invasion of Ukraine. 
The facts are that Donald Trump was first impeached for withholding military aid to a friendly nation in exchange for a purported favor from that nation (Ukraine) against a potential opponent (Joe Biden) of his, in the upcoming presidential elections, at the time. Trump’s feckless presidency and rudderless leadership strengthened Putin’s hand politically, as it relates to the former Soviet Republics, Ukraine especially, from a strategic standpoint -geopolitically. 

Tuesday

The saga of transactional sex on the campus of Nigerian universities

CC™ Editorial By Oludayo Tade 

Transactional sex among female undergraduates in Nigeria is a social reality. The practice has been reported on regularly in the mainstream media and explored in various research papers

This cross generational relationship is widespread in sub-Saharan Africa, and across the world where sponsors are commonly known as “sugar daddies”.

In our study on transactional sex in Nigerian universities, my colleague and I looked at the symbiotic relationship between some female Nigerian undergraduate students and aristos – wealthy, married or unmarried men. The students have transactional sex with the aristos in exchange for financial, social or educational support.

Because a great deal of these relationships happen undercover, there are no solid figures on the number of women involved in them. But there are many reasons that these relationships happen. It’s a practice that’s driven by economic hardship, a desire to network socially, and peer influence.
To understand more about these relationships we conducted 30 interviews with female undergraduates – commonly known as “runs-girls”.
We found that the students engage in transactional sex for pleasure and money. Typically, wealthy students would be with an aristo for pleasure, while those who needed financial support did it for the money. Most of the women we spoke to viewed it as a critical survival life investment strategy and rejected the “prostitution” label.
Although these relationships could offer the students economic, emotional, and political support, their effects can also be negative. The students expose themselves to sexually transmitted infections, physical violence and academic setbacks, because the relationships can distract from their studies.
Those with sexually transmitted infections risk spreading these to their boyfriends, while also suffering economic losses seeking treatment.

Finding clients

Aristos are usually wealthy postgraduate students, lecturers, politicians, business people and military personnel. They are people with wealth and authority.
The students looked for these clients on and off campus, using connections and referrals. They then familiarized themselves with the potential client’s routine, aiming to eventually manufacture an encounter.
There’s usually a generational gap between the “runs-girls” and the aristos. The students often refer to their clients as “uncle”, “daddy” and, more recently, “aristo”. All of these bring connotations of the person’s expected role: to take care of the student.
If the students don’t have much financial support from their families, these relationships provide them with that security. Some started as a one-off “date”, for which they got a sum of money. But longer-term relationships also developed in some instances.
In return for sex, the women were given luxury possessions, like cars and mobile phones; investments for businesses they might start; or work placements when they finish their studies.
As one female student said:
The type of connection I have with politicians, lecturers, and military men cannot be purchased with money. At times, when I have problem, all I do is to make a call, depending on the nature of challenges…
In Nigeria, about 23% of young people are unemployed. These connections, with people of influence, may be a ticket to employment. As one “runs-girl” revealed:
One of my clients who happened to be a commissioner connected my senior sister to get a job at immigration even without any much stress…
Transactional sex isn’t limited to financially strapped students. We spoke to rich female students who engaged in it for sexual fulfillment. One 24 year old student said:
I am from a rich home, my father is even a Major (in the army), and my mother a nurse, but I’m involved in campus runs because of sexual satisfaction, although nothing goes for nothing, because sex is for enjoyment. I have a guy that I help financially, and on the long run he pays me back with sex.

Challenges

In this research we identified a few challenges.
Some “runs-girls” accepted offers of unprotected sex for better pay. This put them at risk of catching sexually transmitted infections and, consequently, the cost of treatment. As one student said:
I am always scared of having naked (unprotected) sex. Most times I use (a) condom because one can never know a man that has HIV/AIDS. Although sometimes some men always want naked sex and in that case, they will have to pay triple than what is earlier bargained. Part of the money realized as a runs-girl are used in revitalizing the body, in which I go to the hospital once in a month to examine myself.
Other risks are that the women could be physically harmed. This is particularly true if the clients choose not to pay an agreed amount.
Their education could also suffer as they may choose to engage in “runs” rather than go to class.

Action needed

Getting the government or even universities to take action will prove difficult because our evidence suggests that policy makers, politicians and the business class are involved, as aristos.
Nevertheless, given the risks associated, something ought to be done.One possible solution might be to establish part-time jobs for vulnerable students, and to institute courses about running businesses so that young women can earn money independently.
In addition, institutions should put together and roll out communications campaigns that teach young people about the implications of transactional sex.

Thursday

The art of managing people

Editor-in-Chief 

Organizations struggle everyday with the germane issue of what the effective management of people, an organization's most prized asset, actually entails. The effective management of people within an organization requires a thorough understanding of the following: 
  
  • Motivation - Whether intrinsic or extrinsic and the importance of positive triggers....
  • Job design and environment....
  • Company's rewards system and how it is structured and also possibly layered....
  • Group influence as a function of Group-think and other allegiances....
Motivation
Human beings are creatures of habit and by that, I mean it is natural to expect that individuals will have different triggers within their genetic and socio-cultural make-up, that ultimately control what their motivations are, where they originate from or worse still, whether or not they have any at all.
Of course, as a business owner or a leader, you would hope you haven't hired someone or lead a group of people on the bottom rung of the Motivation Trigger Index™ (MTI).
Usually, one finds that most people with intrinsic motivation tend to have a higher MTI. They are the high achievers and are usually not driven to succeed or excel necessarily as a result of positive external triggers, but do so because it is just in their make-up. It is however important to note that for these group, the Positive External Triggers (PETs) only serve to further elevate their MTI scores. As for those, whose Motivational Intelligence (MI) require external triggers, they tend to be either in the middle or the lower rung of the Motivation Trigger Index™. People in this category tend to require an appreciable amount of Positive External Triggers (PETs) and ironically, if they have quite a bit of this, they are bound to excel at their tasks, in some cases, even with distinction. However, unlike the first group, their MTI scores tend to vacillate between just above average to poor, as a function of the amount of PETs they are exposed to in their work and related environment.
Job Design and Environment
Over the years, scientific management has sought to strip workers of their initiative, thus ridding the work environment of key intangibles such as skill set diversity, autonomy and most important of all, feedback, constructive or otherwise.
A perfect example of empowering employees and creating an environment that engenders optimum productivity and creativity is to seek input from your employees, even when you, as a leader, know what the solution to a problem is. They may even suggest the solution you have in mind and you can give them credit for it.
Rewards System
The rewards system must be one that does not give rise to suspicion or insinuations of favoritism. While majority of organizations, big or small, insist on building a "team atmosphere", it is imperative that top performers, particularly those that most closely espouse the company's core principles within the framework of its corporate culture, are duly rewarded and recognized as such.
This process should however be carefully monitored and managed, so as to ensure that everyone (including the non-monetary contributors) feels a sense of belonging to the organization, through their own respective contributions.
It is a well-known fact that the successful execution of a company's business strategy must involve everyone on the ship.
Group Influence
This can either be a "good thing" or a "bad thing", but it depends on how you look at it. Now, while it can create a negative work environment due to its potentially divisive and mostly political nature, it is an unavoidable phenomenon.
Most organizations have learned to not only exist but also flourish with just the "right amount" of group-think, as it actually may engender a spirit of collaboration towards reaching the ultimate objectives of the organization.
The overriding attitude becomes one where the conclusion is that if the company wins, then everyone wins. 

© 2024 2CG MEDIA. Coker Confidential™

Wednesday

The Creation of the (Hebrew) Bible

CC™ Perspective

“The Bible was written and revised in specific historical and cultural circumstances and contexts….”

Tuesday

Bloomberg makes $600 million contribution to Howard University and 3 other top Black medical schools

CC™ NewsDay

Michael Bloomberg's organization Bloomberg Philanthropies announced a $600 million gift to the endowments of four historically Black medical schools. 

Bloomberg, the former New York City mayor and the billionaire founder of Bloomberg LP, made the announcement Tuesday in New York at the annual convention of the National Medical Association, an organization that advocates for African American physicians. 

"This gift will empower new generations of Black doctors to create a healthier and more equitable future for our country," Bloomberg said in a statement.

Black Americans fare worse in measures of health compared with white Americans, an Associated Press series reported last year. Experts believe increasing the representation among doctors is one solution that could disrupt these long-standing inequities. In 2022, only 6% of U.S. physicians were Black, even though Black Americans represent 13% of the population.

The gifts are among the largest private donations to any historically Black college or university, with $175 million each going to Howard University College of Medicine, Meharry Medical College and Morehouse School of Medicine. Charles Drew University of Medicine & Science will receive $75 million. Xavier University of Louisiana, which is opening a new medical school, will also receive a $5 million grant. 

The donations will more than double the size of three of the medical schools' endowments, Bloomberg Philanthropies said.

The commitment follows a $1 billion pledge Bloomberg made in July to Johns Hopkins University that will mean most medical students there will no longer pay tuition. The four historically Black medical schools are still deciding with Bloomberg Philanthropies how the latest gifts to their endowments will be used, said Garnesha Ezediaro, who leads Bloomberg Philanthropies' Greenwood Initiative.

The initiative, named after the community that was destroyed during the race massacre in Tulsa, Oklahoma more than 100 years ago, was initially part of Bloomberg's campaign as a Democratic candidate for president in 2020. After he withdrew from the race, he asked his philanthropy to pursue efforts to reduce the racial wealth gap and so far, it has committed $896 million, including this latest gift to the medical schools, Ezediaro said.

In 2020, Bloomberg granted the same medicals schools a total of $100 million that mostly went to reducing the debt load of enrolled students, who schools said were in serious danger of not continuing because of the financial burdens compounded by the COVID-19 pandemic. 

"When we talked about helping to secure and support the next generation of Black doctors, we meant that literally," Ezediaro said. 

Valerie Montgomery Rice, president of Morehouse School of Medicine, said that gift relieved $100,000 on average in debt for enrolled medical students. She said the gift has helped her school significantly increase its fundraising.

"But our endowment and the size of our endowment has continued to be a challenge, and we've been very vocal about that. And he heard us," she said of Bloomberg and the latest donation.

Previous largest single donation to an HBCU

In January, the Lilly Endowment gave $100 million to The United Negro College Fund toward a pooled endowment fund for 37 HBCUs. That same month, Spelman College, a historically Black women's college in Atlanta, received a $100 million donation from Ronda Stryker and her husband, William Johnston, chairman of Greenleaf Trust.

Denise Smith, deputy director of higher education policy and a senior fellow at The Century Foundation, said the gift to Spelman was the largest single donation to an HBCU that she was aware of, speaking before Bloomberg Philanthropies announcement Tuesday. 

Smith authored a 2021 report on the financial disparities between HBCUs and other higher education institutions, including the failure of many states to fulfill their promises to fund historically Black land grant schools. As a result, she said philanthropic gifts have played an important role in sustaining HBCUs, and pointed to the billionaire philanthropist and author MacKenzie Scott's gifts to HBCUs in 2020 and 2021 as setting off a new chain reaction of support from other large donors.

"Donations that have followed are the type of momentum and support that institutions need in this moment," Smith said. 

Dr. Yolanda Lawson, president of the National Medical Association, said she felt "relief," when she heard about the gifts to the four medical schools. With the Supreme Court's decision striking down affirmative action last year and attacks on programs meant to support inclusion and equity at schools, she anticipates that the four schools will play an even larger role in training and increasing the number of Black physicians.

"This opportunity and this investment affects not only just those four institutions, but that affects our country. It affects the nation's health," she said. 

Utibe Essien, a physician and assistant professor at the David Geffen School of Medicine at UCLA, who researches racial disparities in treatment, said more investment and investment in earlier educational support before high school and college would make a difference in the number of Black students who decide to pursue medicine. 

He said he also believes the Supreme Court decision on affirmative action and the backlash against efforts to rectify historic discrimination and racial inequities does have an impact on student choices. 

"It's hard for some of the trainees who are thinking about going into this space to see some of that backlash and pursue it," he said. "Again, I think we get into this spiral where in five to 10 years we're going to see a concerning drop in the numbers of diverse people in our field."

Source: The Associated Press - AP

Monday

World Cup Classics: 1994 World Cup - Nigeria vs Bulgaria

CC™ VideoSpective 

Discovery: Scientists ‘switch off’ autism symptoms using $3 epilepsy drug

CC™ HealthWatch

By Adriana Diaz

Scientists are reporting a breakthrough discovery: A $3-per-pill epilepsy drug may be used to “switch off” autism symptoms in mice, according to a new peer-reviewed study published Tuesday in Molecular Psychiatry journal.

Autism spectrum disorder is a complex developmental condition that impacts how an estimated 5.4 million (2.2% of) adults — and one in 44 children — in the United States perceives and socializes with others. It is often accompanied by abnormalities such as epilepsy or hyperactivity, according to Centers for Disease Control and Prevention data.

A team of experts at Germany’s Hector Institute for Translational Brain Researchfound that the medication lamotrigine — an anti-seizure drug first approved for use in the US in 1994 — was able to curb behavioral and social problems linked to the disorder.

Now, their findings are being hyped as the closest thing yet to a potential cure for humans.

“Apparently, drug treatment in adulthood can alleviate brain cell dysfunction and thus counteract the behavioral abnormalities typical of autism,” lead researcher and cellular biologist Moritz Mall said in a statement. “[This occurs] even after the absence of MYT1L has already impaired brain development during the developmental phase of the organism.”

Lamotrigine, which is sold under the brand name Lamictal, among others, is a medication used to treat epilepsy and stabilize mood in those who suffer from bipolar disorder.

The drug, which typically sells for just under $3 per pill, works by reversing changes to brain cells caused by a genetic mutation.

Scientists have spent years searching forthe molecular abnormalities that contribute to ASD and have identified MYT1L protein as one that plays a role in various neuronal diseases. 

The protein is a so-called transcription factor produced by almost all the nerve cells in the body that decides which genes are or are not active in the cell. It also “protects the identity of nerve cells by suppressing other developmental pathways that program a cell towards muscle or connective tissue.”

Mutations of the protein have previously been linked to other neurological diseases and brain malformations. 

To test impact of the protein on autism symptoms, researchers at HITBR genetically “switched off” MYT1L in mice and human nerve cells. They found that this led to electrophysiological hyperactivation in the mouse and human neurons impairing nerve function. 

The mice lacking MYT1L suffered from brain abnormalities and showed several behavioral changes typical to ASD, such as social deficits or hyperactivity.

Researchers noted that the most “striking” reaction was the discovery that the MYT1L-deficient neurons produced extra sodium channels that are typically restricted to cells in the heart muscle. 

These proteins are critical for electrical conductivity and cell function as they allow sodium ions to travel through the cell membrane. Nerve cells that overproduce these sodium channels can result in electrophysiological hyperactivation — a common symptom of autism.

“When MYT1L-deficient nerve cells were treated with lamotrigine, their electrophysiological activity returned to normal. In mice, the drug was even able to curb ASD-associated behaviors such as hyperactivity,” the statement continued.

These promising results come as autism rates have skyrocketed in the NYC metro area. Autism diagnoses have tripled in the New York-New Jersey metro area: from 1% of the population in 2000 to 3% in 2016

It is believed that part of the drastic increase of these diagnoses is due to the growing number of diagnoses of children without intellectual disabilities, which are therefore less likely to have been identified previously.

But earlier, more accurate diagnoses don’t completely explain the upward trend, which was based on estimates from the CDC. Experts have warned that the growing trend of women giving birth later in life may be partly responsible for the rise. 

Meanwhile, clinical human trials studying lamotrigine’s impact on MYT1L are being planned — and while the research is currently limited to mice, the results are promising, researchers stressed.

SOURCE:  NYP

Tuesday

Tesla Full Self-Driven Almost Crashes

CC™ VideoSpective

Tuesday

Thursday

Monday

White Privilege for Dummies

CC™ VideoSpective

Thursday